Name the site$(s)$ of pyruvate synthesis. Also,write the chemical reaction wherein pyruvic acid dehydrogenase acts as a catalyst.

(N/A) Pyruvate is synthesized in the cytoplasm of the cell during the process of glycolysis.
During glycolysis,one molecule of glucose $(C_6H_{12}O_6)$ is broken down into two molecules of pyruvic acid $(CH_3COCOOH)$.
The enzyme complex pyruvic acid dehydrogenase catalyzes the oxidative decarboxylation of pyruvic acid to form Acetyl $CoA$. This reaction requires $NAD^+$,Coenzyme $A$ $(CoA)$,and $Mg^{2+}$ as cofactors.
The chemical reaction is as follows:
$\text{Pyruvic acid} + CoA + NAD^+ \xrightarrow{Mg^{2+}, \text{Pyruvate dehydrogenase}} \text{Acetyl } CoA + NADH + H^+ + CO_2 \uparrow$